gastrin/cholecystokinin type b receptor

Click ligand names to check details of the ligands. The two receptor isoforms may contribute to functional differences in gastrin- and CCK-mediated signal transduction.". Il Song, David R. Brown, Rodney N. Wiltshire, Ira Gantz, Jeffrey M. Trent, Tadataka Yamada, Research output: Contribution to journal › Article. institution. title = "The human gastrin/cholecystokinin type B receptor gene: Alternative splice donor site in exon 4 generates two variant mRNAs". CCK2 receptor CCK2-R CHOLREC Cholecystokinin-2 receptor {ECO:0000303|PubMed:11926817} cholecystokinin-2 receptor [ Show all] Disease: Diagnostic imaging Duodenal ulcers Gastroesophageal reflux disease Gastrointestinal disease Intestine cancer. WILTSHIREt?, IRA GANTZ1, JEFFREY M. The two receptor isoforms may contribute to functional differences in gastrin- and CCK-mediated signal transduction. The gene contained a 1356-bp open reading frame consisting of five exons interrupted by 4 introns and was assigned to human chromosome 11p15.4. Introduction 805 II. AU - Brown, David R. AU - Wiltshire, Rodney N. AU - Gantz, Ira. T2 - Alternative splice donor site in exon 4 generates two variant mRNAs. Mol Pharmacol. The human gastrin/cholecystokinin type B receptor gene: Alternative splice donor site in exon 4 generates two variant mRNAs, Alternative splice junction/chromosome 11. be of particular importance. © 1993 National Academy of Sciences Genomic clones encoding a human gastrin/CCKB receptor were isolated by screening a human EMBL phage library with a partial-length DNA fragment which was based on the nucleotide sequence of the canine gastrin receptor. The gene contained a 1356-bp open reading frame consisting of five exons interrupted by 4 introns and was assigned to human chromosome 11p15.4. A region of exon 4, which encodes a portion of the putative third intracellular loop, appears to be alternatively spliced to yield two different mRNAs, one containing (452 amino acids; long isoform) and the other lacking (447 amino acids; short isoform) the pentapeptide sequence Gly-Gly-Ala-Gly-Pro. JSTOR®, the JSTOR logo, JPASS®, Artstor®, Reveal Digital™ and ITHAKA® are registered trademarks of ITHAKA. The gastrin receptor was originally cloned from an expression cDNA library constructed with canine parietal cell messenger RNA (mRNA) and was found to be identical to the cholecystokinin-B (CCK–B) receptor (CCK-BR) cloned at about the same time by other laboratories from rat brain and the rat pancreatic acinar carcinoma cell line, AR42J. Semin Nucl Med 32: 97–109, 2002. Together they form a unique fingerprint. Proceedings of the National Academy of Sciences of the United States of America

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