von willebrand factor

Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. Non-serious adverse events include allergic symptoms in under 6% of patients, chills, phlebitis, edema, pain in the limbs, and pseudothrombocytopenia in a few patients. Updates? If you’re a woman with VWD and heavy periods, your treatment may also include birth control pills.

Morayma Reyes Gil MD, PhD, in Transfusion Medicine and Hemostasis (Third Edition), 2019. If you’re going to have a dental procedure, you may need to take aminocaproic acid or tranexamic acid.

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There are three types of inherited VWD and one type of the disorder that isn’t hereditary.

While ristocetin co-factor activity is considered by many to be the ‘gold standard’ it is labor-intensive and difficult to standardize among laboratories.64, George A. Fritsma, in Rodak's Hematology (Sixth Edition), 2020. You’ll also likely develop anemia (low iron in the blood). They include: If you’re a woman with VWD, you’ll have periods with clots larger than an inch in diameter.

Von Willebrand factor (vWF, or VWF), glycoprotein that plays an important role in stopping the escape of blood from vessels (hemostasis) following vascular injury.

Type 3 patients treated with VWF-containing products should be monitored for the appearance of inhibitors directed against VWF and/or FVIII.

By signing up for this email, you are agreeing to news, offers, and information from Encyclopaedia Britannica. From: Hemophilia and Von Willebrand Disease, 2018, In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. von Willebrand factor (factor VIII-related antigen) is a large glycoprotein that is present in the plasma and endothelium and binds to other proteins, particularly factor VIII, preventing its rapid degradation. As a result, you will need to be on fluid restrictions if you’re taking the medication. How Long Does Coronavirus Live On Surfaces?

Recent studies using transgenic mouse models and transplantations demonstrate that endothelial-derived VWF is necessary for hemostasis (prevention of blood loss), whereas platelet-derived VWF is more important for clot formation and stability. Platelet-derived VWF is important for platelet adhesion, aggregation, and thrombus formation. The circulating vWF is the largest protein of the hemostatic system. VWD is the most common inherited bleeding disorder.

No cases of thrombosis have been reported in clinical trials, although caution should be taken in patients with von Willebrand disease who have other thrombotic susceptibility factors [1]. There are more than 300 mutations in the VWF gene that can cause von Willebrand disease, a condition characterized by reduced or delayed clot formation, which results in prolonged bleeding following vascular injury. Data suggest that macrophages and hepatocytes internalize and clear VWF in a process that is independent of multimer size and mediated by lipoprotein receptor-related protein and asialoglycoprotein receptor in both cell types and sialic-acid-binding-immunoglobulin-like-lectin 5 in macrophages.

When VWF is active, it exists in an unfolded form, which exposes its platelet-binding domains and thus allows it to bind to the glycoprotein complexes on platelets. You can inherit Type 1 or Type 2 if one of your parents passes the gene on to you.

C-type lactic domain family 4 member M on endothelial cells has also been shown to mediate VWF clearance in a glycan-dependent manner.

This article was most recently revised and updated by, https://www.britannica.com/science/von-Willebrand-factor, Cornell University College of Veterinary Medicine - Eclinpath - Von Willebrand Disease, Genetics Home Reference - Von Willebrand Factor.

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